Listeria monocytogenes 10403S HtrA is necessary for resistance to cellular stress and virulence.
نویسندگان
چکیده
The HtrA serine protease has been shown to be essential for bacterial virulence and for survival after exposure to many types of environmental and cellular stresses. A Listeria monocytogenes 10403S htrA mutant was found to be sensitive to oxidative and puromycin-induced stress at high temperatures, showed a reduced ability to form biofilms, and was attenuated for virulence in mice.
منابع مشابه
The htrA (degP) gene of Listeria monocytogenes 10403S is essential for optimal growth under stress conditions.
This report describes a mutant of Listeria monocytogenes strain 10403S (serotype 1/2a) with a defective response to conditions of high osmolarity, an environment that L. monocytogenes encounters in some ready-to-eat foods. A library of L. monocytogenes clones mutagenized with Tn917 was generated and scored for sensitivity to 4% NaCl in order to identify genes responsible for growth or survival ...
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ورودعنوان ژورنال:
- Infection and immunity
دوره 74 1 شماره
صفحات -
تاریخ انتشار 2006